Are hydrolyzed sodium hyaluronate and hydrolyzed hyaluronic acid the same?

Ⅰ.hyaluronic acid vs sodium hyaluronate

Hyaluronic acid and sodium hyaluronate are not essentially the same product.However,in most practical applications and products, HA=hyaluronic acid=Sodium Hyaluronate.

1. Hyaluronic acid

Hyaluronic acid is commonly known as HA. Hyaluronic acid naturally exists in our body and is widely distributed in human tissues such as eyes, joints, skin, and umbilical cord. Originating from the inherent properties of human substances, this also ensures its application safety. Hyaluronic acid has a special water retention effect and can absorb about 1000 times its own weight of water, making it internationally recognized as the most ideal natural moisturizing factor. Hyaluronic acid also has good physical and chemical properties and biological functions such as lubricity, viscoelasticity, biodegradability, and biocompatibility.

However, hyaluronic acid has one “downside”:The content of hyaluronic acid in the human body gradually decreases with age. Data shows that at the age of 30, the hyaluronic acid content in the skin of the human body is only 65% of that in infancy, and drops to 25% by the age of 60, which is also one of the important reasons for the loss of skin elasticity and luster.

Therefore, the full utilization and widespread application of hyaluronic acid cannot be achieved without the drive and development of technological innovation.

2. Sodium hyaluronate

Sodium hyaluronate is the sodium salt form of hyaluronic acid, which is relatively stable and has strong penetration, making it easier to penetrate and be absorbed. Hyaluronic acid is an acid, and sodium hyaluronate is a sodium salt.

Sodium hyaluronate is the sodium salt form of hyaluronic acid, which is relatively stable and has strong penetration, making it easier to penetrate and be absorbed. Hyaluronic acid is an acid, and sodium hyaluronate is a sodium salt. Sodium hyaluronate can exist in the form of a sodium salt and be reduced to hyaluronic acid after entering the body. We can understand it this way: sodium hyaluronate is the “front stage”, hyaluronic acid is the “back stage”. It can also be explained as follows: Sodium hyaluronate is the substance that wears sodium salt on clothing, and it is still hyaluronic acid that truly replenishes the body and exerts its effects. Sodium hyaluronate is stable, the production process is mature, the PH is nearly neutral and basically non-irritating, the molecular weight range is wide, can be produced to meet the different needs of the market, so it has been widely used in the market, in our common cosmetics and food publicity hyaluronic acid, hyaluronic acid and so on actually refers to sodium hyaluronate.

3. Difference between sodium hyaluronate and hyaluronic acid

The difference of sodium hyaluronate and hyaluronic acid, is that the two have large differences in product properties due to structural differences.

From the perspective of CAS numbers, the CAS number for sodium hyaluronate is 9067-32-7, while that for hyaluronic acid is 9004-61-9.

From the perspective of molecular structure, the two have the same main structure. The difference lies in that when the R position of the carboxyl group is connected to a hydrogen ion, it is hyaluronic acid; when it is connected to a sodium ion, it is sodium hyaluronate.

In terms of pH, the pH of hyaluronic acid is relatively low, ranging from 3 to 5, while the pH of sodium hyaluronate is close to neutral, generally ranging from 5.0 to 8.5.And the low PH of hyaluronic acid leads to poor product stability. The production process is also more complex than sodium hyaluronate, and the low PH is acidic resulting in a certain irritation, limiting the application of the product, so it is not common in the market.

Therefore, in most practical applications and products, HA=hyaluronic acid=Sodium Hyaluronate.

II.hydrolyzed sodium hyaluronate vs hydrolyzed hyaluronic acid

1. Hydrolyzed sodium hyaluronate

Cosmetics commonly used sodium hyaluronate, are relatively large molecular weight structure, skin external use, is not conducive to absorption basically stay on the stratum corneum.Therefore, the polymer sodium hyaluronate is degraded by biological enzymes or other special methods to obtain sodium hyaluronate with a smaller molecular weight, which is called “hydrolyzed sodium hyaluronate“.The molecular weight of sodium hyaluronate hydrolyzed is generally less than 10kDA.

2. Hydrolyzed hyaluronic acid

The low PH of hydrolyzed hyaluronic acid leads to poor product stability. The production process is also more complex than hydrolyzed sodium hyaluronate, and the low PH is acidic resulting in a certain irritation, limiting the application of the product, so it is not common in the market.Some people believe that the molecular weight of hydrolyzed hyaluronic acid must be below 10kDa, but some people think that the molecular weight below 50kDa is hydrolyzed hyaluronic acid.

3. Difference between hydrolyzed sodium hyaluronate and hydrolyzed hyaluronic acid

Hydrolyzed hyaluronic acid and hydrolyzed sodium hyaluronate are not the same product. Hydrolyzed sodium hyaluronate and hydrolyzed hyaluronic acid are different forms of the same substance, with the same core active ingredient and core efficacy in skin care. The only difference lies in whether they contain sodium ions, which directly affects their solubility and the convenience of application in cosmetics.

Hydrolyzed hyaluronic acid itself has a relatively low solubility in water and dissolves slowly. Sodium hyaluronate hydrolyzed has extremely high water solubility and can dissolve quickly and evenly in water. This characteristic makes sodium hyaluronate hydrolyzed a more popular raw material in cosmetic formulas.

In addition,the PH of hydrolyzed hyaluronic acid sold on the market is generally between 2.5 and 5.0,while the pH of hydrolyzed sodium hyaluronate is close to neutral, generally ranging from 5.0 to 8.5.

Renew is a professional factory that produces sodium hyaluronate. We have fresh stock of sodium hyaluronate and support free samples. If you have any requirements for sodium hyaluronate raw materials, please feel free to contact us at any time.